This presentation provides an overview of the many ways digital health platforms- working in concert with AI, wearable sensors, virtual reality (VR) and augmented reality (AR) technologies – are poised to profoundly improve the efficiency and extend the reach of healthcare delivery. Next-Generation AI, VR, and AR-enabled clinical systems are being developed and validated that facilitate the shift the locus of clinical care from the hospital and the clinic to the home and the workplace and, via improved analytics, provide tools and systems that enable personalized and precision medicine. We know from decades of clinical research that VR/AR technologies can provide breakthrough solutions that address the most difficult problems in healthcare such as mood disorders, anxiety, depression, PTSD, addictions, autism, cognitive aging, stroke recovery, and physical rehabilitation, to name just a few. Individualized health and wellness protocols, as well as treatment plans, can be provided via portable systems that integrate wearable sensors, VR, AR, and AI technologies to effectively promote adherence and encourage healthy lifestyles. As the cost of healthcare rises, wearable systems integrated with AI, VR and AR technologies are poised to address difficult health problems, to reduce the costs of care delivery, and to significantly improve clinical efficiency.